研究方向

利用多组学数据整合分析方法，解析重要农作物及林木生长发育的调控生物学基础，从而为其精准遗传改良奠定理论依据。相关工作亦涉及生物医药领域多组学大数据的研究，在多组学方法学层面开展跨领域的应用探索。

学习、工作经历

2024/11-至今：北京林业大学生物科学与技术学院，遗传学学科，讲师

2021/01-2024/10：中国科学院北京基因组研究所（国家生物信息中心），特别研究助理（博士后）

2015/09-2021/01：中国科学院北京基因组研究所（国家生物信息中心），博士

2010/07-2015/06：哈尔滨医科大学生物信息科学与技术学院，学士

承担项目

1）2025/11-2027/11 林木遗传育种全国重点实验室（北京林业大学）2025年度科技创新项目“基于多组学的杨树木材形成调控网络与机制研究”(主持)；

2）2025/07-2027/07 北京林业大学新进教师科研启动基金“杨树维管形成层发育的表观遗传调控机制研究”(主持)；

3）2025/01-2028/12 国自然基金面上项目“调控型信使RNA大规模鉴定的生物信息学方法”(参与)；

4）2024/06-2025/06 北京林业大学开放基金“杨树响应胶孢炭疽菌侵染关键基因识别及功能分析”(主持)；

5）2022/01-2023/12 中国博士后科学基金第71批面上一等资助“基于多组学数据整合分析的胶质瘤关键长非编码RNA识别及功能研究”(主持)；

6）2022/01-2023/12 中国科学院特别研究助理资助项目“脑疾病多组学数据整合分析及数据库构建”(主持)。

成果与奖励

1) 2021：北京市普通高等学校优秀毕业生

2) 2020：博士研究生国家奖学金

3) 2019：中国科学院大学“三好学生”称号

4) 2015：哈尔滨医科大学优秀毕业论文

5) 2013：全国大学生数学建模竞赛黑龙江省一等奖

6) 2013：国家励志奖学金

发表论文情况

1. Tan SX#, Guo H, Wang HF, Wu JD, Liu L*, Bao F*, Xie JB*: PopMYB4 orchestrates disease resistance through H3K36me3-mediated epigenetic activation of PopGSTU7 in poplars, New Phytologist, 2026 Apr;250(1):454-471.

2. Tan SX#, He DY#, Si JN#, Wang RT, Li Y, Xu F, Zhang J, Guo H, Du YX, Cheng Z, Wang HF, Liu L*, Xie JB*: The PopGRF3-PopKNAT3 module orchestrates salt tolerance through transcriptional control of stress-responsive genes in poplar, New Phytologist, 2026 Mar; doi: 10.1111/nph.71096.

3. Liu SJ#, Tan SX#, Li Q#, He DY, Xu L, Zhang H, Wang RT, Guan YM, Cheng Z, Wu JD, Xu W, Zhang HT, Tang M, Fan JL, Liu L, Xie JB*: PagMYB74 orchestrates flavonoid-mediated plant-microbe feedback for drought resilience in poplar, New Phytologist, 2026 Mar 16; doi: 10.1111/nph.71086.

4. Wang T#, Wang HF#, Si JN#, Wu JD, Zhang C, Yang S, Cao XF, Zhang X, Li Y, EI-Kassaby YA, Liu L, Zhang DQ, Chen Z*, Xie JB*: The PagGRF20-PagMYB4 regulatory module coordinates wood formation in poplar, Journal of Integrative plant biology, 2026 Feb 9; doi: 10.1111/jipb.70176.

5. Wu JD#, Liu SJ#, Zhang HY, Chen SS, Si JN, Liu L, Wang Y, Tan SX, Du YX, Jin ZL, Xie JB*, Zhang DQ*: Flavones enrich rhizosphere Pseudomonas to enhance nitrogen utilization and secondary root growth in Populus, Nature Communications, 2025, 16(1): 1461.

6. Gao Y#, Yang Y#, Wei J, Yue J, Wang Y, Zhang Q, Jin M, Wang R, Yang X, Zhang J, Liu X, Liu L, Zhang Y, Yang R*: LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection. Cell Mol Immunol, 2023. 20(5):475-488.

7. Li Z#, Liu L#, Feng CR#, Qin YX, Xiao JF, Zhang Z*, Ma LN*: LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations. Nucleic Acids Research, 2022. doi: 10.1093/nar/gkac999.

8. Ma LN#*, Zou D#, Liu L#, Shireen, H, Abbasi, A., Bateman, Alex, Xiao JF, Zhao WM, Bao YM, Zhang Z*: Database Commons: a catalog of worldwide biological databases. Genomics, Proteomics & Bioinformatics, 2022. S1672-0229(22)00169-3

9. Liu L as co-first author in CNCB-NGDC Members and Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. Nucleic Acids Research, 2023. 51(D1):D18-D28. doi: 10.1093/nar/gkac1073.

10. Liu L#, Zhang Y#, Niu GY#, Li QP, Li Z, Zhu TT, Feng CR, Liu XN, Zhang YS, Xu TY, Chen RR, Teng XF, Zhang RQ, Zou D, Ma LN*, Zhang Z*: BrainBase: a curated knowledgebase for brain diseases. Nucleic Acids Research, 2022, 50 (D1): D1131-D1138.

11. Liu L#, Li Z#, Liu C#, Zou D, Li QP, Feng CR, Jing W, Luo SC, Zhang Z*, Ma LN*: LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system. Nucleic Acids Research, 2022, 50(D1): D190-D195.

12. Liu L as co-first author in Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022. Jan 7;50(D1): D27-D38. doi: 10.1093/nar/gkab951.

13. Li Z#, Liu L#, Jiang S, Li QP, Feng CR, Du Q, Zou D, Xiao JF, Zhang Z*, Ma LN*: LncExpDB: an expression database of human long non-coding RNAs. Nucleic Acids Research, 2021, 49 (D1): D962-D968.

14. Liu L#, Wang GY#, Wang LG, Yu CL, Li MW, Song SH, Hao LL, Ma LN*, Zhang Z*: Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling. Biology Direct, 2020, 15: 10.

15. Ma LN#, Cao J#, Liu L#, Du Q, Li Z, Zou D, Bajic VB, Zhang Z*: LncBook: a curated knowledgebase of human long non-coding RNAs. Nucleic Acids Research, 2019, 47: D128-D134.

16. Ma LN*, Cao J#, Liu L#, Li Z, Shireen H, Pervaiz N, Batool F, Raza R, Zou D, Bao YM, Abbasi AA, Zhang Z*: Community curation and expert curation of human long non-coding RNAs. Current Protocols in Bioinformatics, 2019, 67 (1): e82.

17. Sang J#, Zou D#, Wang Z, Wang F, Zhang Y, Xia L, Li Z, Ma LN, Li M, Xu BX Liu X, Wu S, Liu L, Niu G, Li M, Luo Y, Hu S, Hao L*, Zhang Z*: IC4R-2.0: Rice genome reannotation using massive RNA-Seq data. Genomics Proteomics & Bioinformatics, 2020. 18 (2):161-172.

18. Niu G#, Zou D#, Li M#, Zhang Y, Sang J, Xia L, Li M, Liu L, Cao J, Zhang Y, Wang P, Hu S, Hao L*, Zhang Z*: Editome Disease Knowledgebase (EDK): A curated knowledgebase of editome-disease associations in human. Nucleic Acids Research, 2019, 47 (D1): D78-D83.

19. Sun J#, Shi H#, Wang Z, Zhang C, Liu L, Wang L, He W, Hao D*, Liu S*, Zhou M*: Inferring novel lncRNA-disease associations based on a random walk model of a lncRNA functional similarity network. Molecular BioSystems. 2014, 10 (8):2074-81.