李中海

植物叶片衰老分子生物学
植物逆境分子生物学
林木分子育种

教育经历
2008 - 2012，理学博士，北京大学
2000 - 2003，理学硕士，中科院动物研究所
1996 - 2000，理学学士，聊城师范学院 

工作经历
2021 - 至今，教授，北京林业大学生物科学与技术学院 
2018 - 2021，青年研究员，北京林业大学林木分子育种高精尖中心 
2016 - 2018，Research Fellow，韩国基础科学研究所植物衰老研究中心
2012 - 2016，博士后，北京大学生命科学学院
2006 - 2008，研究助理，北京大学生命科学学院
2003 - 2006，助理研究员，国家人类基因组南方研究中心

国家自然科学基金委面上项目“拟南芥多肽激素CLE42调控叶片衰老的分子机制”，2022-01-01至2025-12-31, 58万，主持
国家自然科学基金委国际(地区)合作与交流项目“植物衰老与木质素合成的互作机制”，2020-10-01至2022-09-30, 15万，主持
国家自然科学基金委面上项目“拟南芥组蛋白变体HTB9调控叶片衰老及木质素合成的分子机制”，2020-01-01至2023-12-31, 58万，主持

第八批中国博士后科学基金特别资助
第56批中国博士后科学基金一等奖 
北大-清华生命科学联合中心优秀博士后基金
北京大学优秀博士后 
北京大学学术创新奖 
北京大学顾温玉生命科学奖学金
北京大学张景钺-李正理奖学金

1. Zhang Yi#, Tan Shuya#, Gao Yuhan, Kan Chengcheng, Wang Hou-Ling, Xia Xinli, Ishida Takashi, Sawa Shinichiro, Guo Hongwei, and Li Zhonghai*. CLE42 Delays Leaf Senescence by Antagonizing Ethylene Pathway in Arabidopsis. New Phytologist, 2022, DOI: 10.1101/2022.02.27.481379.

2. Daniela Liebsch#, Marta Juvany#, Li Zhonghai#, Wang Hou-Ling, Agnieszka Ziolkowska, Daria Chrobok , Clément Boussardon, Wen Xing, Simon R. Law, Helena Jane?ková, Bastiaan Brouwer, Pernilla Lindén, Nicolas Delhomme, Hans Stenlund, Thomas Moritz, Per Gardestr?m, Guo Hongwei* and Olivier Keech*. Metabolic Control of Arginine and Ornithine Levels Paces the Progression of Leaf Senescence. Plant Physiology, 2022. Accepted.

3. Huang Peixin, Guo Hongwei* and Li Zhonghai*. New Advances in the Regulation of Leaf Senescence by Classical and Peptide Hormones. Frontier in Plant Science, 2022, Accepted.

4. Wang Hou-Ling, Yang Qi, Tan Shuya, Wang Ting, Zhang Yi, Yang Yanli, Yin Weilun, Xia Xinli, Guo Hongwei and Li Zhonghai*. Regulation of Cytokinin Biosynthesis Using PtRD26pro-IPT Module Improves Drought Tolerance through PtARR10-PtYUC4/5-Mediated Reactive Oxygen Species Removal in Populus. Journal of Integrative Plant Biology, 2022, DOI: 10.1111/jipb.13218

5. Tan Shuya, Cao Jie, Xia Xinli, and Li Zhonghai*. Advances in 5-Aminolevulinic Acid Priming to Enhance Plant Tolerance to Abiotic Stress. International Journal of Molecular Sciences, 2022, 23(2), 702

6. Zhang Yue-Mei, Guo Pengru, Xia Xinli, Guo Hongwei and Li Zhonghai*. Multiple Layers of Regulation on Leaf Senescence: New Advances and Perspectives. Frontier in Plant Science, 2021, 12: 788996.

7. Zhang Yi#, Gao Yuhan#, Wang Hou-Ling#, Kan Chengcheng, Li Ze, Yang Xiufen, Yin Weilun, Xia Xinli, Nam Hong Gil, Li Zhonghai* and Guo Hongwei*. Verticillium dahliae secretory effector PevD1 induces leaf senescence by promoting ORE1-mediated ethylene biosynthesis. Molecular Plant, 2021,14(11): 1901-1917.

8. Gao Yuhan#, Li Ze#, Yang Chengyu, Li Guangyue, Zeng Hongmei, Li Zhonghai, Zhang Yi*, and Yang Xiufen*. Pseudomonas syringae activates ZAT18 to inhibit salicylic acid accumulation by repressing EDS1 transcription for bacterial infection. New Phytologist, 2021, DOI: 10.1111/nph.17870

9. Wang Hou-Ling#, Zhang Yi#, Wang Ting, Yang Qi, Yang Yanling, Li Ze, Li Bosheng, Wen Xing, Li Wenyang, Yin Weilun, Xia Xinli, Guo Hongwei*, and Li Zhonghai*. Alternative splicing variant of PtRD26 delays leaf senescence by regulating multiple NAC transcription factors in Populus. Plant Cell, 2021, 33: 1594–1614.

10. Kan Chengcheng#, Zhang Yi#, Wang Hou-Ling, Shen Yingbai, Xia Xinli, Guo Hongwei*, and Li Zhonghai*. Transcription factor NAC075 delays leaf senescence by deterring reactive oxygen species accumulation in Arabidopsis. Frontier in Plant Science, 2021, 12: 634040.

11. Guo Yongfeng#, Ren Guodong#, Zhang Kewei#, Li Zhonghai#, Miao Ying*, and Guo Hongwei*. Leaf senescence: progression, regulation, and application. Molecular Horticulture, 2021, 1: 5. 

12. Li Zhonghai#,*, Zhang Yang#, Zou Dong, Zhao Yi, Wang Hou-Ling, Zhang Yi, Xia Xinli, Luo Jingchu, Guo Hongwei and Zhang Zhang*. LSD 3.0: a comprehensive resource for the leaf senescence research community. Nucleic Acids Research, 2020, D1069–D1075. 

13. Li Zhonghai#, Kim Jin Hee#, Kim Jeongsik, Lyu Jae Il, Guo Hongwei, Nam Hong Gil* and Woo Hye Ryun*. ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis. New Phytologist, 2020, 227: 473–484.

14. Zhang Yi, Wang Hou-Ling, Gao Yuhan, Guo Hongwei* and Li Zhonghai*. SATMF suppresses the premature senescence phenotype of the ATM loss-of-function mutant and improves its fertility in Arabidopsis. International Journal of Molecular Sciences, 2020, 21(21), 8120

15. Wang Hou-Ling, Zhang Yi, Xia Xinli, Yin Weilun, Guo Hongwei and Li Zhonghai*. Research advances in leaf senescence of woody plants. Scientia Sinica (Vitae), 2020, 50: 196-206.

16. Zhang Yi, Wang Houling, Li Zhonghai* and Guo Hongwei*. Genetic network between leaf senescence and plant immunity: crucial regulatory nodes and new insights. Plants, 2020, 9, 495.

17. Yang Yanli, Li Hui-Guang, Wang Jie, Wang Hou-Ling, He Fang, Su Yanyan, Zhang Ying, Feng Cong-Hua, Niu Mengxue, Li Zhonghai, Liu Chao, Yin Weilun, Xia Xinli *. ABF3 enhances drought tolerance via promoting ABA-induced stomatal closure by directly regulating ADF5 in Populus euphratica. Journal of Experimental Botany, 2020, 71(22): 7270-7285.

18. Wang Hou-Ling, Guo Hongwei and Li Zhonghai*. Gene network analysis of senescence-associated genes in annual plants and comparative assessment of aging in perennials and animals. Translational Medicine of Aging, 2019, 3: 6-13.

19. Li Zhonghai and Guo Hongwei. Ethylene Treatment in Studying Leaf Senescence in Arabidopsis. Methods In Molecular Biology, 2018, 1744: 105-112. 

20. Li Zhonghai, Woo Hye Ryun* and Guo Hongwei*. Genetic redundancy of senescence-associated transcription factors in Arabidopsis. Journal of Experimental Botany, 2018, 69: 811-823.

21. Guo Pengru#, Li Zhonghai#, Huang Peixin, Li Bosheng, Fang Shuan, Chu Jinfang and Guo Hongwei*. A tripartite amplification loop involving the transcription factor WRKY75, salicylic acid, and reactive oxygen species accelerates leaf senescence. Plant Cell, 2017, 29: 2854–2870.（Web of science高被引论文）

22. Li Zhonghai, Zhao Yi, Liu Xiaochuan, Jiang Zhiqiang, Peng Jinying, Jin Jinpu, Guo Hongwei* and Luo Jingchu*. Construction of the leaf senescence database and functional assessment of senescence-associated genes. Methods In Molecular Biology: Plant Genomics Databases, 2017, 1533: 315-333. 

23. Li Zhonghai#, Zhao Yi#, Liu Xiaochuan, Peng Jinying, Guo Hongwei* and Luo Jingchu*. LSD 2.0: An update of the leaf senescence database. Nucleic Acids Research, 2014, 42: D1200–D1205.

24. Peng Jinying#, Li Zhonghai#, Wen Xing, Li Wenyang, Shi Hui, Yang Longshu, Zhu Huaiqiu and Guo Hongwei*. Salt-Induced Stabilization of EIN3/EIL1 Confers Salinity Tolerance by Deterring ROS Accumulation in Arabidopsis. PLoS Genetics, 2014, 10(10): e1004664.

25. Li Zhonghai#, Peng Jinying#, Wen Xing and Guo Hongwei*. Ethylene-insensitive3 is a senescence-associated gene that accelerates age-dependent leaf senescence by directly repressing miR164 transcription in Arabidopsis. Plant Cell, 2013, 25: 3311-3328. (Featured by Faculty of 1000)（Web of science高被引论文）

26. Li Zhonghai, Peng Jinying, Wen Xing and Guo Hongwei*. Gene network pathways and functional studies of senescence associated genes reveal novel regulators of Arabidopsis leaf senescence. Journal of Integrative Plant Biology, 2012, 54(8): 526-639.

27. Liu Xiaochuan#, Li Zhonghai#, Jiang Zhiqiang, Zhao Yi, Peng Jinying, Jin Jinpu, Guo Hongwei* and Luo Jingchu*. LSD: a leaf senescence database. Nucleic Acids Research, 2011, 39: D1103-D1107.

学术会议报告

1. National Postgraduate Symposium on Forest Tree Genetic Breeding. Oct. 27-30, 2020, Jingzhou, Hubei, China. (Oral presentation)

2. The 3rd National Conference on Plant Flowering, Senescence and Postharvest. Nov. 4-7, 2019, Hangzhou, China. (Oral presentation).

3. The 9th International Symposium on Plant Senescence, April 1-4, 2019, Berlin, Germany. (Oral presentation).

4. The XIX International Botanical Congress (IBC). Jul.23-29, 2017, Shenzhen, China. (Oral presentation).

5. The 8th International Symposium on Plant Senescence. Oct.31-Nov.4, 2016, Jeju, Korea (Poster)

6. 26th International Conference on Arabidopsis Research (ICAR). Jul. 5-9. 2015, Paris, France. (Poster)

7. 25th International Conference on Arabidopsis Research (ICAR). Jul. 28 - Aug. 1, 2014, Vancouver, Canada. (Oral presentation). 

8. The 1st National Conference on Plant Flowering, Senescence and Postharvest. Aug. 16-18, 2010, Shanghai, China. (Oral presentation).

9. The 351st Xiangshan Conference on "Plant Senescence and Crop Yield and Quality Improvement". June 2-6, 2009, Beijing, China. 

专利情况

1. 李中海、王厚领、张易、夏新莉、郭红卫，编码小肽PFER的基因序列、小肽PFER和应用及诱导树木生根的方法，专利号：ZL201910639857.0 

2. 李中海、张易、王厚领、夏新莉、郭红卫，蛋白激酶ATM基因序列、应用及调控植物叶片衰老进程的方法，专利号：ZL201910639850.9 

3. 李中海、王厚领、张易、夏新莉、郭红卫，YLB9基因序列、应用及调控植物木质素合成中的方法，专利号：ZL201910640108.X   

4. 郭红卫、李中海，TAG1基因在调控植物叶片衰老进程中的应用。2015，中国，专利号：ZL 2015 1 0796550.3

5. 郭红卫、李中海、彭金英，SAM1基因在增强植物抗高盐耐受中的应用。2013，中国，专利号：ZL 2011 1 0158812.5